Tuberculosis Vaccine
Modified BCG including ESAT-6 provides improved protection
Published in TB and Outbreaks Week, April 29th, 2003
BCG and other live tuberculosis vaccines "lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early secretory antigenic target) and CFP-10 (10-kDa culture filtrate protein)," explained A.S. Pym and colleagues at the Pasteur Institute in Paris and the Liverpool School of Tropical Medicine in Liverpool, U.K.
Recombinant vaccines including these antigens provided superior protection against tuberculosis, Pym and coauthors said.
BCG and the M....
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