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Pneumococcal Vaccine

Immunogenic protein contaminants found in pneumococcal vaccines

Published in TB and Outbreaks Week, April 29th, 2003

Lots of pneumococcal vaccines contaminated with immunogenic proteins could produce variable results in vaccine testing or antibody assays.

"Currently available pneumococcal vaccines were examined for contamination by pneumococcal surface protein A (PspA) and pneumococcal surface adhesin A (PsaA). PspA could be detected in some (but not all) lots of 23-valent polysaccharide vaccine. Many lots of pneumococcal vaccines, including the heptavalent conjugate vaccine, were found to elicit small (but variable) antibody responses to PspA, PsaA, or both," scientists in the United States report.

"The degree of contamination was highly variable, and this should...

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