Tuberculosis Therapy

DNA polymerase gene linked to drug resistance

Published in TB and Outbreaks Week, May 6th, 2003

by Michael Greer, senior medical writer - Researchers in the United States have identified a Mycobacterium tuberculosis gene which plays a key role in the development of mycobacterial drug resistance.

"The presence of multiple copies of the major replicative DNA polymerase (DnaE) in some organisms, including important pathogens and symbionts, has remained an unresolved enigma," according to Helena I.M. Boshoff and colleagues at the National Institute of Allergy and Infectious Diseases in Rockville, Maryland, who "postulated that one copy might participate in error-prone DNA repair synthesis."

Boshoff and coauthors mapped this function to the...

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Source: TB and Outbreaks Week (2003-05-06)

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