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Leprosy

Sitofloxacin effective for treatment

Published in TB and Outbreaks Week, June 3rd, 2003

Sitofloxacin is effective for the treatment of leprosy, alone or in combination with other antimycobacterial agents.

According to a study from the United States, "the antimicrobial effects of sitafloxacin (DU-6859a) against Mycobacterium leprae, either singly or in combination with either rifampicin, rifabutin or KRM-1648, were studied using a mouse footpad assay technique and the results were compared with those obtained with ofloxacin."

"When used singly, the minimum concentrations of sitafloxacin and ofloxacin needed to inhibit completely the growth of M. leprae were 25 and 100 mg per kg body weight per day, respectively, and the...

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