Tuberculosis Pathogenesis

Lymphotoxin beta receptor plays key role in infection control

Published in TB and Outbreaks Week, June 3rd, 2003

by Michael Greer, senior medical writer - Researchers in Germany have identified a molecule that plays a key role in immune response to tuberculosis and other infections.

"Containment of intracellularly viable microorganisms requires an intricate cooperation between macrophages and T cells, the most potent mediators known to date being IFN [interferon]-gamma and TNF [tumor necrosis factor]," explained Stefan Ehlers and colleagues at the Research Center Borstel in Borstel, the Technical University of Munich, and the University of Regensburg.

The lymphotoxin beta receptor (LTbetaR) also mediates immune control of Mycobacterium tuberculosis and...

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Source: TB and Outbreaks Week (2003-06-03)

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