Staphylococcal Infection

Enterotoxin H induces Valpha-specific T-cell expansion

Published in TB and Outbreaks Week, June 3rd, 2003

Staphylococcal enterotoxin H (SEH) triggers Valpha-specific T-cell expansion.

SEH "is a bacterial superantigen secreted by Staphylococcus aureus," researchers in Sweden explained. "Superantigens are presented on the MHC class II and activate large amounts of T cells by cross-linking APC and T cells."

In a recent study by K. Petersson and coauthors at Active Biotech Research AB, "RT-PCR was used to show that SEH stimulates human T cells via the Valpha domain of TCR, in particular Valpha10 (TRAV27), while no TCR Vbeta-specific expansion was seen."

"This is in sharp contrast to all other studied bacterial superantigens, which...

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Source: TB and Outbreaks Week (2003-06-03)

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