Tuberculosis Proteomics

Rv3133c/DosR is a transcription factor involved in infection latency

Published in TB and Outbreaks Week, June 3rd, 2003

The mycobacterial protein Rv3133c/DosR is a transcription factor, and plays a key role in establishing latent tuberculosis infection.

"Unlike many pathogens that are overtly harmful to their hosts, Mycobacterium tuberculosis can persist for years within humans in a clinically latent state," scientists in the United States explained. "Latency is often linked to hypoxic conditions within the host."

"Among the M. tuberculosis genes induced by hypoxia is a putative transcription factor, Rv3133c/DosR," according to H.D. Park and coauthors at the University of Washington, who "performed targeted disruption of this locus followed by...

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Source: TB and Outbreaks Week (2003-06-03)

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