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Tuberculosis Diagnosis

Novel immunoassay improves detection of latent infection

Published in TB and Outbreaks Week, June 10th, 2003

by Michael Greer, senior medical writer - A novel immunoassay can improve the diagnosis of latent tuberculosis infection, researchers say.

"The diagnosis of latent tuberculosis infection relies on the tuberculin skin test (TST), which has many drawbacks," according to Katie Ewer and colleagues at the University of Oxford and the Institute of Health Sciences in Oxford, United Kingdom, the Leicestershire Health Authority in Leicestershire, and the Statens Serum Institute in Copenhagen, Denmark.

An enzyme-linked immunospot (ELISPOT) test developed by Ewer and coauthors proved more accurate than TST in identifying British schoolchildren with latent...

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