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Smallpox

Virus researchers close in on the secret life of DNA

Published in TB and Outbreaks Week, June 10th, 2003

Z-DNA, a long-known but still mysterious alternate configuration of DNA, is involved in cellular defenses against viral attack according to the results of a series of experiments linking Z-DNA binding proteins with lethality in pox viruses.

The research may point toward important answers to the unsolved puzzle of how this alternate form of DNA functions and may lead to the development of antiviral compounds that are effective against smallpox, one of the deadliest of human diseases.

A report on the research by two teams of scientists from the Massachusetts Institute of Technology and Arizona State University appeared in the May 19, 2003 online early...

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