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Infectious Disease Therapy

Flexible-duration ceftriaxone regimen effective against typhoid fever

Published in TB and Outbreaks Week, June 17th, 2003

A variable-duration ceftriaxone regimen is effective against typhoid fever in children.

"Although the efficacy of ceftriaxone in typhoid fever is well documented, the precise duration of ceftriaxone therapy in children with typhoid fever is not established and varies from 3 to 14 days in the literature," scientists in Turkey noted.

"In a prospective, randomized study ceftriaxone was compared with chloramphenicol for treatment of 72 children who had bacteriologically confirmed typhoid fever," according to M.M. Tatli and coauthors at Harran University in Sanliurfa.

"Ceftriaxone was given at a dose of 75 mg/kg per day (maximally 2...

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