Infectious Disease

B cells not needed for Cryptosporidium defense

Published in TB and Outbreaks Week, June 24th, 2003

B cells have little if any role in host defense against Cryptosporidium parasites.

In a study from Canada, "the importance of B cells in host resistance to, and recovery from," C. parvum infection "was examined in gene-targeted B cell-deficient (muMT-/-) mice."

"Neonatal muMT-/- mice infected with C. parvum at five days of age completely cleared the infection by day 20 PI," according to W.X. Chen and coauthors working at the National Research Council of Canada. "The kinetics of infection and clearance were similar to those seen with age-matched C57BL/6 control mice."

"Furthermore, B cells were not required to...

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Source: TB and Outbreaks Week (2003-06-24)

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