Tuberculosis Immunology

Macrophages and mesothelial cells secrete pleural interleukin-8

Published in TB and Outbreaks Week, June 24th, 2003

Pleural mesothelial cells and macrophages produce interleukin (IL)-8 during tuberculosis infection.

IL-8 "plays an important role in the host immune response to Mycobacterium tuberculosis by recruiting inflammatory cells to the site of infection," researchers in South Korea explained.

In their study, J.S. Park and colleagues at Dankook University in Cheonan "investigated the role of pleural macrophages and mesothelial cells in the production of IL-8 in tuberculous pleurisy."

"Large concentrations of IL-8 were detected in tuberculous pleural effusions, but not in pleural effusions associated with congestive heart failure...

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Source: TB and Outbreaks Week (2003-06-24)

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