Staphylococcal Infection
S. aureus vancomycin susceptibility affected by mprF gene
Published in TB and Outbreaks Week, July 8th, 2003
In a study from the United States, a chemically generated S. aureus RN4220 mutant, "GC6668, was isolated that had a fourfold increase in resistance to vancomycin."
"This phenotype reverted back to susceptibility by insertional mutagenesis with Tn917," noted A. Ruzin and colleagues working at Wyeth Research in Pearl River, New York.
"In a selected set of revertants, Tn917 insertion was mapped to a unique chromosomal region upstream of mprF, a recently described gene that determines staphylococcal resistance...
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