Streptococcus Pneumoniae

Sortase gene srtA appears to be involved in adhesion to host pharynx

Published in TB and Outbreaks Week, July 8th, 2003

The sortase gene srtA of Streptococcus pneumoniae appears to be involved in adhesion to host pharyngeal cells.

According to recent research published in the journal Infection and Immunity, "Inactivation of sortase gene srtA in Streptococcus pneumoniae strain R6 caused the release of beta-galactosidase and neuraminidase A (NanA) from the cell wall into the surrounding medium. Both of these surface proteins contain the LPXTG motif in the C-terminal domain.

"Complementation with plasmid-borne srtA reversed protein release. Deletion of murM, a gene involved in the branching of pneumococcal peptidoglycan, also caused partial release...

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Source: TB and Outbreaks Week (2003-07-08)

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