Mycobacteria

Highly polymorphic gene region useful for strain identification

Published in TB and Outbreaks Week, July 15th, 2003

A highly variable region of the mycobacterial genome is useful for strain identification.

"Sequence analysis of a specific region of the mycobacterium rpoB gene in 35 mycobacterial strains representing 26 different mycobacterial species of clinical importance showed that there exists a highly polymorphic region," H. Lee and coauthors at Yonsei University in South Korea wrote.

"Based on the sequences of the polymorphic region, the oligonucleotide probes of 14 mycobacterial species with relatively high clinical importance were designed and shown to be specific to their corresponding mycobacterial species by dot blot hybridization," according to...

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Source: TB and Outbreaks Week (2003-07-15)

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