Bacillus Anthracis

Virulence gene regulator atxA controls many genes, acpA controls few

Published in TB and Outbreaks Week, July 15th, 2003

The Bacillus anthracis virulence regulatory genes atxA and acpA play different roles; atxA controls many genes, while acpA controls few.

According to a study from the United States, "Control of anthrax toxin and capsule synthesis, the two major virulence factors of Bacillus anthracis, has been associated with two regulatory genes, atxA and acpA, located on virulence plasmids pXO1 and pXO2, respectively.

"We used transcriptional profiling to determine whether atxA and/or acpA control genes other than those already described, and to investigate functional similarities of the regulators. Transcription was assessed in a pXO1+ pXO2+ parent...

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Source: TB and Outbreaks Week (2003-07-15)

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