Streptococcus Pneumoniae

RegR, though nonessential, regulates competence, adherence, and virulence

Published in TB and Outbreaks Week, July 15th, 2003

Streptococcus pneumoniae's RegR, though nonessential, regulates competence, adherence, and virulence.

"The homolactic and catalase deficient pathogen Streptococcus pneumoniae is not only tolerant to oxygen but requires the activity of its NADH oxidase, Nox, to develop optimal virulence and competence for genetic transformation. In this work, we show that the global regulator RegR is also involved in these traits. Genetic dissection revealed that RegR regulates competence and the expression of virulence factors, including hyaluronidase," investigators in France report.

"In bacteria grown in vitro, RegR represses hyaluronidase. At neutral...

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Source: TB and Outbreaks Week (2003-07-15)

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