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Systemic Infection

Improved test design may still yield appropriate immunotherapy for sepsis

Published in TB and Outbreaks Week, August 5th, 2003

Better test design may yield better answers for what immunomodulatory therapy may improve sepsis and lower risk.

According to a study from the United States, "Despite decades of research, the morbidity and mortality of sepsis and septic shock remain very high. To further compound the problem, results from all investigative trials (with 1 exception) have shown that tested immunotherapies aimed at modulating the excessive expression of key cytokines, such as the interleukins and tumor necrosis factor, have been either equivalent or inferior to placebo. While controversy prevails in terms of continuing such investigative trials, study designs can be held accountable for...

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