Helicobacter Pylori
Supernatants cause cytoskeletal disruption, not related to VacA toxin
Published in TB and Outbreaks Week, August 12th, 2003
Recent research from England shows "that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis."
The researchers "demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constructing VacA null isogenic mutants, we show that the effect is not due to the vacuolating cytotoxin."
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