Epstein-Barr Virus
Stem cell transplantation with donor lymphocyte infusions can resolve chronic EBV infection
Published in TB and Outbreaks Week, August 19th, 2003
In a recent study from Japan, a patient with chronic active EBV infection "was treated by allogeneic SCT from an HLA-identical sibling donor, using a nonmyeloablative regimen."
"Even on day 70, mixed chimerism remained together with a quite high viral load," noted M. Hagihara and colleagues at Tokai University. "On days 76 and 90, donor lymphocytes were infused after short-term culture with OKT3 plus recombinant IL-2."
"At 8 days after the last dose, all hematopoietic cells were shown to be donor-type...
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