Published in TB and Outbreaks Week, August 19th, 2003
MTB "persists inside macrophages despite vigorous immune responses," scientists in the United States noted. "MTB and MTB 19-kDa lipoprotein inhibit class II MHC (MHC-II) expression and Ag [antigen] processing by a Toll-like receptor 2-dependent mechanism".
In their study, R.K. Pai and coauthors at Case Western Reserve University found that this mechanism involves "a defect in IFN-gamma induction of class II transactivator (CIITA)."
"Exposure of macrophages to MTB or MTB 19-kDa lipoprotein...
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