Tuberculosis Pathogenesis
Mycobacterial suppression of INFgamma-induced CIITA protects against host immune response
Published in TB and Outbreaks Week, August 19th, 2003
MTB "persists inside macrophages despite vigorous immune responses," scientists in the United States noted. "MTB and MTB 19-kDa lipoprotein inhibit class II MHC (MHC-II) expression and Ag [antigen] processing by a Toll-like receptor 2-dependent mechanism".
In their study, R.K. Pai and coauthors at Case Western Reserve University found that this mechanism involves "a defect in IFN-gamma induction of class II transactivator (CIITA)."
"Exposure of macrophages to MTB or MTB 19-kDa lipoprotein...
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