Immunology

NF-kappaB plays role in gammaherpesvirus latency

Published in TB and Outbreaks Week, September 9th, 2003

Nuclear factor kappaB (NF-kappaB) appears to play a key role in the establishment of gammaherpesvirus latency in infected patients.

"Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections," scientists in the United States explained. "Members of this virus family are characterized by their ability to establish latent infections in lymphocytes."

"The latent viral genome expresses very few gene products. The infected cells are therefore poorly recognized by the host immune system, allowing the virus to persist for long periods of time," noted H.J. Brown and colleagues at the...

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Source: TB and Outbreaks Week (2003-09-09)

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