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Malaria Immunology

Age is key determinant of IgG response to Plasmodium falciparum

Published in TB and Outbreaks Week, September 23rd, 2003

Age is a key factor determining the immunoglobulin G (IgG) humoral response to malaria infection.

"Immune responses directed at glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum may offer protection against symptomatic malaria," scientists in the United States explained.

"To independently explore the effect of age on generation of the anti-GPI IgG response," S.N.H. Keenihan and colleagues at the U.S. Navy Medical Research Unit 2 at the American Embassy in Jakarta "measured serum anti-GPI IgGs in a longitudinal cohort of migrant Javanese children (6-12 years old) and adults (greater than or equal to 20 years old) with...

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