Antibiotics

GABA(A) receptor blockade underlies cephalosporin-induced convulsions

Published in TB and Outbreaks Week, September 30th, 2003

GABA(A) receptor blockade underlies cephalosporin-induced convulsions.

"There is accumulating evidence that most beta-lactam antibiotics (i.e, cephalosporins and penicillins) have some degree of convulsive activity, both in laboratory animals as well as in clinical settings," scientists in Japan explained. "The proposed mechanism is suppression of inhibitory postsynaptic responses, mainly mediated by gamma-amino butyric acid (GABA)(A)-receptors (GABA(A)-R). However, comprehensive studies on the convulsive activities of various beta-lactam antibiotics in vivo and in vitro have not been performed."

M. Sugimoto and colleagues at Osaka University...

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Source: TB and Outbreaks Week (2003-09-30)

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