Antifungal Therapy

Assay for itraconazole drug monitoring developed

Published in TB and Outbreaks Week, September 30th, 2003

An assay for determining itraconazole levels in treated patients has been developed.

Published research from Germany described a "method for the simultaneous quantification of the antifungal drug itraconazole and its co-active metabolite hydroxyitraconazole in plasma employing liquid chromatography tandem-mass spectrometry and automated solid-phase extraction".

"The method proved rugged, enables short turn-around times and is highly specific," reported M. Vogeser and coauthors working at the University of Munich.

"Since there is growing evidence for the importance of therapeutic drug monitoring of itraconazole in the prophylaxis...

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Source: TB and Outbreaks Week (2003-09-30)

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