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Drug Development

Novel carbapenem has improved anti-MRSA activity

Published in TB and Outbreaks Week, September 30th, 2003

A novel carbapenem antibiotic has demonstrated improved activity against MRSA and other pathogens.

According to published research from Japan, "a series of 10-methylcarbapenems bearing an (imidazo[5,1-b]thiazolium-6-yl)methyl moiety, a 5,5-fused heterobicycle, at the C-2 position was synthesized and evaluated for in vitro antibacterial activities."

"CP0569 (1r) and its analogues showed potent antibacterial activities against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Gram-negative bacteria, including Pseudomonas aeruginosa," reported K. Aihara and coauthors working at Meiji Seika Kaisha...

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