Pathogenesis

Salmonella SpvB disrupts host cell actin cytoskeleton, induces apoptosis

Published in TB and Outbreaks Week, September 30th, 2003

Salmonella SpvB disrupts host cell actin cytoskeleton and induces apoptosis.

According to a study from Japan, "The spv genes carried on the Salmonella virulence plasmid are commonly associated with severe systemic infection in experimental animals.

"The SpvB virulence-associated protein has been shown to ADP-ribosylate actin, and this enzymatic activity is essential for virulence in mice," wrote A. Kurita and colleagues, Kitasato University, Kitasato Institute Life Science.

The researchers concluded: "Here we present evidence that intracellular expression of SpvB protein induces not only disruption of actin...

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Source: TB and Outbreaks Week (2003-09-30)

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