Clostridium Perfringens
CaCo-2 cells have concentration-dependent responses to CPE enterotoxin
Published in TB and Outbreaks Week, October 7th, 2003
"Clostridium perfringens enterotoxin (CPE), a 35-kDa polypeptide, induces cytotoxic effects in the enterocyte-like CaCo-2 cell culture model. To identify the mammalian cell death pathway(s) mediating CPE-induced cell death, CaCo-2 cultures were treated with either 1 or 10 microg of CPE/ml. Both CPE doses were found to induce morphological damage and DNA cleavage in CaCo-2 cells," scientists in the United States report.
"The oncosis inhibitor glycine, but not a...
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