Drug Development
Mycobacterial arabinogalactan linkage disaccharide analogs block cell wall biosynthesis
Published in TB and Outbreaks Week, October 14th, 2003
"The mycobacterial arabinogalactan linkage disaccharide [alpha-(L)-Rha-(1 --> 3)-alpha-D-GlcNAc] provides a basis for the design of new antitubercular drugs, since it supports a key skeletal structure in the bacterial cell wall," scientists in Canada explained.
In a study conducted by X.H. Wen and colleagues at the University of Manitoba, "A series of analogues of the linker was synthesized by coupling appropriate thiorhamnosyl donors modified at their 4-positions, with an N-acetyl glucosamine acceptor."
"In a cell-free enzyme...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB and Outbreaks Week
More Articles from TB and Outbreaks Week
- Drug Development
Potent inhibitors of M. tuberculosis TMPK developed - Infectious Disease
Rab5 activity, iron access needed for mycobacterial arrest of phagosome maturation - Malaria Therapy
Azadirachta indica derivatives not practical for malaria treatment - Tuberculosis Immunology
TDM needed for macrophage infection with M. tuberculosis - Tuberculosis Latent Infection
M. tuberculosis Rel needed for latent TB infection - AIDS Prevention
Studies to look at role of alcohol in HIV risk in heterosexual women - More from this issue of TB and Outbreaks Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
