Published in TB and Outbreaks Week, October 14th, 2003
"The mycobacterial arabinogalactan linkage disaccharide [alpha-(L)-Rha-(1 --> 3)-alpha-D-GlcNAc] provides a basis for the design of new antitubercular drugs, since it supports a key skeletal structure in the bacterial cell wall," scientists in Canada explained.
In a study conducted by X.H. Wen and colleagues at the University of Manitoba, "A series of analogues of the linker was synthesized by coupling appropriate thiorhamnosyl donors modified at their 4-positions, with an N-acetyl glucosamine acceptor."
"In a cell-free enzyme...
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