Published in TB and Outbreaks Week, October 14th, 2003
According to recent research from Germany, "Helicobacter pylori (Hp) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells.
"We found that VacA could efficiently block proliferation of T cells by inducing a G1 /S cell cycle arrest. It interfered with the T-cell receptor/IL-2 signaling pathway at the level of the Ca2+ calmodulin-dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T cells (NFAT), a transcription factor acting as a global regulator of...
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