Helicobacter Pylori

H. pylori blocks T cell activation with vacuolating cytotoxin A

Published in TB and Outbreaks Week, October 14th, 2003

T-cell proliferation is blocked by Helicobacter pylori vacuolating cytotoxin A by arresting the cell cycle.

According to recent research from Germany, "Helicobacter pylori (Hp) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells.

"We found that VacA could efficiently block proliferation of T cells by inducing a G₁ /S cell cycle arrest. It interfered with the T-cell receptor/IL-2 signaling pathway at the level of the Ca²⁺ calmodulin-dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T cells (NFAT), a transcription factor acting as a global regulator of...

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Source: TB and Outbreaks Week (2003-10-14)

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