Tuberculosis Latent Infection
M. tuberculosis Rel needed for latent TB infection
Published in TB and Outbreaks Week, October 14th, 2003
"Long-term survival of nonreplicating Mycobacterium tuberculosis (Mtb) is ensured by the coordinated shutdown of active metabolism through a broad transcriptional program called the stringent response," scientists in the United States explained.
In a recent study, J.L. Dahl and coauthors at the National Institute of Allergy and Infectious Disease found that the Mtb stringent response is "initiated by the enzymatic action of Rel[Mtb]", and that "deletion of rel[Mtb] produces a strain (H37RvDeltarel[Mtb]) severely compromised in the...
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