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Malaria

Placental Plasmodium falciparum infection alters neonatal immune responses

Published in TB and Outbreaks Week, October 21st, 2003

Placental Plasmodium falciparum infection alters neonatal immune responses.

In a recent study from Gambia, "The effects of exposure to placental malaria infection on newborn immunological responses, in particular Th1/Th2 cytokines and antigen-presenting cell (AFC) function, were compared between cord blood mononuclear cells (CBMC) from parasitized and non-parasitized placentas of Gambian women."

"Cells were analyzed in vitro for their ability to respond to mitogens [phorbol myristate acetate (PMA)/ ionomycin, phytohaemagglutinin (PHA)], a malaria-unrelated test antigen [purified protein derivative of Mycobacterium tuberculin [purified...

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