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Bacteriology

Transposome-based mutagenesis improves study of Bartonella henselae

Published in TB and Outbreaks Week, November 11th, 2003

A transposome-based mutagenesis technique may aid the study of B. henselae.

"Molecular genetics are difficult to perform in Bartonella henselae, the causative agent of cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and bacillary peliosis," scientists in Germany explained. "To elucidate the underlying bacterial pathogenic mechanisms, genetic manipulation of B. henselae is the method of choice."

T. Riess and colleagues at the University of Tuebingen developed a novel method for "transposon mutagenesis in B. henselae using transposome technology."

"B. henselae...

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