Tuberculosis Pathogenesis
M. tuberculosis virulence linked to mitochondrial cytochrome c release
Published in TB and Outbreaks Week, November 11th, 2003
"Mitochondria are at the center of molecular events involved in energy production, cell survival and apoptosis," scientists in Mexico explained. "Mitochondrial membrane potential (Deltapsi(m)) is maintained by cellular catabolic reactions and the electron transport chain of which cytochrome c is a constituent, whereas the proton leak pathway, ATP synthesis and turnover consume it."
"Mitochondrial alterations such as a drop in Deltapsi(m), swelling and cytochrome c release have been observed in apoptosis," noted E....
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