Genomics and Genetics

Fold recognition improves study of M. tuberculosis genome

Published in TB and Outbreaks Week, November 18th, 2003

A novel technique improves study of the M. tuberculosis genome.

In a recent study from France, "Fold recognition was applied to the systematic analysis of the all sequences encoded by the genome of Mycobacterium tuberculosis H37Rv in order to identify new putative glycosyltransferases."

"The search was conducted against a library composed of all known crystal structures of glycosyltransferases and some related proteins," explained M. Wimmerova and coauthors at Joseph Fourier University in Grenoble.

"A clear relationship appeared between some sequences and some folds," they found. "It appears necessary to complete...

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Source: TB and Outbreaks Week (2003-11-18)

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