Malaria Therapy
Prognostically useful P. falciparum genetic markers identified
Published in TB and Outbreaks Week, November 18th, 2003
According to recent research from Uganda, "Surveillance of molecular markers for key mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) has been proposed as a means of predicting sulfadoxine/pyrimethamine (SP) treatment outcomes in Africa."
D. Kyabayinze and coauthors at Makerere University "assessed the association between DHFR and DHPS mutations and standardized clinical outcomes in children treated with SP for uncomplicated malaria in Kampala, Uganda."
"Two mutations (DHFR Asn-108 and...
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