Trichinosis Research

IL-10 appears to be protective to liver infected with Trichinella spiralis

Published in TB and Outbreaks Week, November 18th, 2003

The liver appears to produce IL-10 in response to Trichinella spiralis infection to protect tissue from necrotic damage, and does not impact the parasite.

"Infection with Trichinella spiralis rarely leads to significant morbidity. In this study, we show that IL-10 knockout mice infected with this parasite develop extensive areas of coagulative necrosis in the liver, and newborn larvae are required for lesion formation. Histopathological examination revealed that the hepatic inflammatory infiltrate was mixed but dominated by eosinophils," scientists in the United States report.

"Accordingly, infected IL-10 knockout mice displayed a...

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Source: TB and Outbreaks Week (2003-11-18)

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