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Tuberculosis Diagnostics

Nucleic acid tests for tuberculous meningitis have limited use

Published in TB and Outbreaks Week, November 25th, 2003

Nucleic acid-based assays have limited use in tuberculous meningitis diagnosis.

"Conventional tests are not always helpful" in making such diagnoses, scientists in the United States noted.

M. Pai and colleagues at the University of California-Berkeley performed "a systematic review and meta-analysis to establish the summary accuracy of nucleic acid amplification (NAA) tests for tuberculous meningitis."

"We searched six electronic databases and contacted authors, experts, and manufacturers," they explained in the journal Lancet Infectious Diseases. "Measures of diagnostic accuracy were pooled using a random effects model."...

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