TB and Outbreaks Week

Malaria Proteomics -  Plasmodium falciparum Rad51 homologue identified

Malaria Therapy - Combination antimalarial therapy can slow spread of drug resistance

Malaria Therapy - Novel beta-diketonate improves synthesis of trioxane antimalarial agents

Malaria Therapy - Oxidative stress underlies antitumor activity of artesunate

Mosquito-borne Disease - Peritrophic matrix limits blood digestion rate in malaria-carrying mosquitos

Nosocomial Infection - Pennsylvania now requires hospital-acquired infections to be reported

Opportunistic Infection -  Mycobacterium xenopi treatment is unnecessary for HIV patients on HAART

Parachlamydia Acanthamoeba - Free-living amoebic pathogen P. acanthamoeba replicates in macrophages

Pertussis Therapy - Azithromycin is an effective treatment for pertussis

SARS - Canada lab to use monkeys for SARS research

SARS - Hospital officials say degenerative bone disorder found in 49 patients

Smallpox - Immune memory from vaccination lasts more than 50 years

Staphylococcal Enterotoxins - New staphylococcal enterotoxin SER may be related to SEG; found in 2 plasmids

Stem-Cell Transplantation - Infliximab raises post-SCT risk of non-Candida invasive fungal infections

Streptococcus Pneumoniae - Brain ciliated ependyma appear to sustain damage during bacterial meningitis

Streptococcus Pneumoniae - Penicillin therapy for S. pneumoniae can create an inflammatory reaction

Streptococcus Pyogenes -  Streptococcus pyogenes HtsA, upregulated in blood, binds one heme molecule

T-Cell Anergy - Chronic exposure to antigen induces IFNgamma-dependent TCR downregulation

Transfusion Medicine - Granulocyte transfusions effective against drug-resistant infection in neutropenic patient

Tuberculosis - IFN-gamma-inducible LRG-47 plays key role in anti-TB immune defense

Tuberculosis Diagnostics - Amplified ribosomal DNA restriction analysis useful for identifying M. tuberculosis

Tuberculosis Diagnostics - Fluorogenic assay enables rapid and accurate TB diagnosis

Tuberculosis Diagnostics - Molecular assay suitable for high-throughput mycobacterial identification

Tuberculosis Drug Resistance - Fully automated assay suitable for identifying pyrazinamide-resistant TB

Tuberculosis Epidemiology - Amplified-fragment length polymorphism typing can complement RFLP

Tuberculosis Immunology - MyD88 primes macrophages for IFN-gamma activation, but has limited role in TB defense

Tuberculosis Proteomics - Mycobacterial heat shock protein HSP16.3 characterized

Tuberculosis Risk Factor -  IL-12B UTR mutation does not affect TB risk

Tuberculous Meningitis - MRI useful for detecting asymptomatic spinal arachnoiditis in TBM patients

West Nile Virus - First human trial of West Nile vaccine to begin

Yersinia Enterocolitica - Some Yersinia enterocolitica biotype 1A appear to have virulence factors