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Tuberculosis Diagnostics

Modified luciferase reporter phages enable rapid detection of TB drug resistance

Published in TB and Outbreaks Week, December 2nd, 2003

A pair of modified luciferase reporter phages (LRPs) enable rapid detection of mycobacterial drug resistance.

LRPs "have proven to be efficient tools for drug susceptibility testing of Mycobacterium tuberculosis," scientists in the United States explained. "Luminometric detection of LRP activity offers higher sensitivity and quantitative results, while a Polaroid film detection method offers a 'low-tech' inexpensive alternative that is called the Bronx box."

In a recent study, M.H. Hazbon and colleagues at the University of Medicine and Dentistry of New Jersey "evaluated, improved, and compared the performance of the luminometer and the Bronx...

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