Enterococcus Faecalis
E. faecalis gains entry into enterocytes by means of Asc10 functional domain
Published in TB and Outbreaks Week, December 2nd, 2003
"Aggregation substance (AS), a surface protein encoded on the pheromone-inducible plasmids of Enterococcus faecalis, has been shown to increase adherence and internalization into a number of different cell types, presumably through integrin binding mediated by the N-terminal RGD motif of AS," investigators in the United States report.
"Here, defined mutations constructed in Asc10, the AS encoded by the plasmid pCF10, are analyzed for their ability to promote increased internalization levels into HT-29...
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