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Helicobacter Pylori

Toxigenic and nontoxigenic H. pylori outer membrane vesicles increase IL-8

Published in TB and Outbreaks Week, December 2nd, 2003

Gastric epithelial cells respond to Helicobacter pylori outer membrane vesicles with IL-8 production, proliferation, whether a toxigenic strain or not.

"Helicobacter pylori infection, which is always associated with gastritis, can progress to ulceration or malignancy. The diversity in clinical outcomes is partly attributed to the expression of virulence factors and adhesins by H. pylori," scientists writing in the journal Infection and Immunity report.

"However, H. pylori may not have to adhere to the epithelium to cause gastritis. We hypothesize that outer membrane vesicles (OMV), which are constantly shed from the...

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