Tuberculosis Immunology
MyD88 primes macrophages for IFN-gamma activation, but has limited role in TB defense
Published in TB and Outbreaks Week, December 2nd, 2003
"Macrophages are activated from a resting state by a combination of cytokines and microbial products," scientists in New York explained. "Microbes are often sensed through Toll-like receptors signaling through MyD88."
In a recent study, S.A.P. Shi and colleagues at Cornell University "used large-scale microarrays in multiple replicate experiments followed by stringent statistical analysis to compare gene expression in wild-type (WT) and MyD88(-/-) macrophages."
"We confirmed...
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