Tuberculosis Proteomics
Mycobacterial heat shock protein HSP16.3 characterized
Published in TB and Outbreaks Week, December 2nd, 2003
According to recent research from China, HSP16.3 "was identified as the major membrane-bound protein of Mycobacterium tuberculosis during stationary phase."
"Previous studies revealed that HSP16.3 was in a nonameric form in solution," noted Y. Chen and coauthors at Tsing Hua University. In their study, the crystallization of "HSP16.3 molecules on a lipid monolayer was obtained for the first time."
"The crystal exhibited p422 symmetry with lattice parameters alpha=beta=90 Angstrom, gamma=90 degrees," the scientists reported. "The...
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