Immune Evolution
Some innate immune system proteins recognize bacterial cell wall peptidoglycan
Published in TB and Outbreaks Week, December 9th, 2003
According to recent research from the United States, "the innate immune system recognizes microorganisms through a series of pattern recognition receptors that are highly conserved in evolution. Peptidoglycan (PGN) is a unique and essential component of the cell wall of virtually all bacteria, and is not present in eukaryotes; thus is an excellent target for the innate immune system.
"Indeed, higher eukaryotes, including mammals, have several PGN recognition molecules, including CD14, Toll-like receptor 2, a family of peptidoglycan...
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