Tuberculosis Pathogenesis
MptpB protein plays key role in M. tuberculosis virulence
Published in TB and Outbreaks Week, December 9th, 2003
According to published research from India, "Protein tyrosine kinases and tyrosine phosphatases from several bacterial pathogens have been shown to act as virulence factors by modulating the phosphorylation and dephosphorylation of host proteins."
"The identification and characterization of two tyrosine phosphatases - namely MptpA and MptpB from Mycobacterium tuberculosis - has been reported earlier," noted R. Singh and coauthors at the University of Delhi. "MptpB is secreted by M. tuberculosis into extracellular mileu and exhibits a pH optimum of 5.6,...
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