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Typhoid

The dark side of good bacteria explored

Published in TB and Outbreaks Week, December 9th, 2003

Beneficial bacteria in the small intestine may be helping more than just the human host they inhabit. They may also help the bacterium that causes typhoid to invade the cells lining the small intestine, say researchers from Harvard Medical School.

The researchers discovered that some bacteria that are normally found in the small intestine (and serve a beneficial function to the host) produce a compound that causes a specific protein to redistribute on the surface of the cells lining the intestine. This makes the cells more susceptible to infection by Salmonella enterica serovar Typhi, the bacterium that causes typhoid, which uses the protein to attach to and...

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