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TB and Outbreaks Week

Susan Hasty, Publisher

Table of Contents . . . December 23rd, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in TB and Outbreaks Week | Other Publications

Drug Development - Targeted norfloxacin prodrugs have antituberculosis activity

Tuberculosis Therapy - MMP inhibitor prevents M. tuberculosis-induced macrophage apoptosis

Drug Development -  Kalopyanax pictus extract has strong antimalarial activity

Drug Development - Protein tyrosine kinase inhibitors show promise for malaria treatment

Tuberculosis Diagnostics - Resazurin microtiter assay cheap, rapid, and accurate for TB resistance testing

Tuberculosis Proteomics - Mycobacterial type III polyketide synthases isolated

Antifungal Therapy - Historical data on therapy of invasive aspergillosis reveals synergy, antagonism

Antifungal Therapy - Pediatric patients may benefit from voriconazole for invasive aspergillosis

Candidiasis - PDE2 induces Candida albicans hyphae production; virulence is not increased

Cat Scratch Disease -  Bartonella henselae IgG can last over a year; symptoms not titer-related

Cytokine Production - Zinc deficiency produces cell-type specific alteration of cytokine expression

Drug Development - Novel manadomanzamines may benefit TB, HIV patients

Encephalitis - Vaccine maker to collaborate with WHO on Japanese vaccine for virus

Finance - MMV to fund clinical development of malaria drug

Food-borne Illness - Chi-Chi's outbreak raises questions about FDA's ability to screen

Food-borne Illness - Cooking ensures safe vegetables, CDC says

Food-borne Illness - Microplate sandwich assay suitable for detection of E. coli O157:H7 in food

Gastroenterology - Bleeding duodenal ulcer repair should be endoscopic if valve surgery is recent

HIV/AIDS Tuberculosis - Chest radiography has limited value in HIV-TB diagnosis

Helicobacter Pylori - Growth phase H. pylori is sensitive to iron starvation, otherwise survives

Helicobacter Pylori - Purified H. pylori CagA, HspB proteins can induce gastric cell division

Immune Evasion -  Streptococcus pyogenes M protein has 2 domains binding complement and IgA

Immunology -  Nramp1-mediated innate resistance mediated by IRF-8

Infectious Diseases - Bacteria use novel mechanism to express genes

Leishmaniasis - Leishmaniasis parasites identified in humans and dogs in eastern Sudan

Liposomal Ciprofloxacin -  Francisella tularensis infection can be treated with liposomal ciprofloxacin

Malaria - Data on DB289 presented at tropical medicine meeting

Malaria - Improved PCR assay sensitively detects avian malaria infection

Malaria Immunology - Natural killer cells have antimalarial activity

Malaria Pathogenesis -  P. yoelli peroxiredoxin expression characterized

Malaria Pathogenesis - Hepatocyte expression of HGF and its receptor needed for malaria infection

Malaria Pathogenesis - Melatonin and N-acetyl-serotonin induce calcium mobilization in malaria parasites

Malaria Therapy - Clindamycin-dihydroartemisinin antimalarial regimen effective

Malaria Therapy - Effect of quinine pharmacokinetics on treatment response elucidated

Microarrays - Synthetic lethality is determined by microarray; DNA helicase genes elucidated

Mosquito-borne Disease - Free bednets for pregnant women effective at reducing infant malaria in Kenya

Mosquito-borne Disease - Temperature effects on An. gambiae aquatic development clarified

New Products - NewsRx expands to 100 titles in Health Law and Business

Nosocomial Infection - Solution to hospital infections could be in the air

Nosocomial Infections - Bacteremia from methicillin-resistant staphylococci problem in Turkish hospital

Parasitology - Alveolar echinococcosis is still a serious environmentally-acquired risk

Pediatric AIDS - Why do most breastfed infants of HIV-positive moms resist infection?

Pertussis - Incidence of pertussis among infants appears to be increasing

Pulmonary Medicine - Bronchodilator therapy may ameliorate TB-induced CAO

SARS - Animal model shows early promise for SARS vaccine

SARS - Better tests needed for diagnosis

SARS - Communication is key to successful U.S. quarantine

Sexually Transmitted Diseases - STDs could increase risk of cervical cancer

Stem-Cell Transplantation - Unrelated donor status has limited impact on post-SCT CMV risk

Tuberculosis Diagnostics - BacT/ALERT 3D system suitable for TB drug resistance screening

Tuberculosis Drug Resistance - Mycobacterial pncA mutations linked to pyrazinamide resistance

Tuberculosis Genomics - Novel mycobacterial phosphoprotein phosphatase identified

Tuberculosis Pathogenesis - Virulent M. tuberculosis downregulates AM apoptosis genes

Tuberculosis Therapy - Permanent ethambutol-induced ocular toxicity reported

Virology - Budding viral hijackers may co-opt cell machinery for the getaway

West Nile Virus - Few WNV-infected animals found in Austria

West Nile Virus - Scientists get images of West Nile pathogen

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