Drug Development
Novel manadomanzamines may benefit TB, HIV patients
Published in TB and Outbreaks Week, December 23rd, 2003
In a recent study from the United States, "Two novel alkaloids, named manadomanzamines A (1) and B (2), were isolated from an Indonesian sponge Acanthostrongylophora sp. (Haplosclerida: Petrosiidae)."
"Their structures were elucidated and shown to be a novel organic skeleton related to the manzamine type alkaloids," according to J.N. Peng and coauthors at the University of Mississippi. "Their absolute configuration and conformation were determined by CID, NOESY, and molecular modeling analysis. The microbial community analysis for the sponge that produces these...
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