Tuberculosis Therapy
MMP inhibitor prevents M. tuberculosis-induced macrophage apoptosis
Published in TB and Outbreaks Week, December 23rd, 2003
In a recent study, scientists in Italy found that "Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94)."
"In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis and the downmodulation of membrane CD14 expression," reported M.B. Santucci and coauthors at the University of Rome. "Moreover, the addition of broad spectrum matrix metalloproteinase inhibitor to cell culture, during MTB infection, decreases the...
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